ADAMTS13 Reflex Panel
Also known as: ADAMTS PAN
Use
The ADAMTS13 Reflex Panel aids in the diagnosis of thrombotic thrombocytopenic purpura (TTP) and helps distinguish between inherited and acquired forms of TTP. The test uses a reflexive approach where additional tests are performed based on initial ADAMTS13 activity results, particularly useful for identifying severe ADAMTS13 deficiency, which is a hallmark of TTP.
Special Instructions
This test is New York state approved. When ordering multiple tests, separate specimens should be submitted for each test to ensure accuracy of results. If the ADAMTS13 activity is less than or equal to 30%, additional reflex testing will be conducted, which may incur additional charges.
Limitations
The test is not cleared or approved by the FDA. Results may be influenced by recent plasma exchange therapy, which can affect ADAMTS13 activity levels. Mild to moderate deficiencies can result from various medical conditions aside from TTP. It is recommended to correlate results with clinical findings for accurate diagnosis.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 53622-7
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
3 mL
Minimum Volume
2 mL
Container
Light blue (sodium citrate)
Collection Instructions
Transfer 3 mL platelet-poor plasma to an ARUP standard transport tube.
Storage Instructions
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Causes for Rejection
Serum, or EDTA plasma. Clotted or hemolyzed specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 2 hours |
| Refrigerated | Unacceptable |
| Frozen | 2 weeks (No freeze/thaw cycles.) |