Aldosterone, Serum
Also known as: ALDOST
Use
Aldosterone, a hormone produced by the adrenal glands, plays a critical role in maintaining blood pressure and sodium balance. Testing for serum aldosterone is pivotal for diagnosing disorders such as hyperaldosteronism and adrenal insufficiency. Elevated levels may suggest primary aldosteronism, while low levels could indicate adrenal insufficiency. The assessment of aldosterone levels in conjunction with renin may provide insights into the body's fluid balance, especially concerning sodium intake and patient posture, which can significantly affect the hormone's concentrations.
Special Instructions
For accurate results, patient preparation is required: collect the specimen midmorning after the patient has been sitting, standing, or walking for a minimum of two hours, followed by sitting for 5-15 minutes. It is important to refer to the Additional Technical Information for optimal patient preparation, especially regarding sodium intake and medication management.
Limitations
Test results may be influenced by the patient's sodium intake and body posture at the time of collection. High sodium intake can suppress, whereas low sodium may elevate, serum aldosterone levels, leading to false readings. The interaction with medications for hypertension could also affect results, and variance in reference intervals based on age, posture, and sodium intake should be considered when interpreting test outcomes.
Methodology
Immunoassay (CLIA)
Biomarkers
LOINC Codes
- 1763-2
Result Turnaround Time
1 day
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Serum Separator Tube (SST) or Plain Red
Collection Instructions
Collect midmorning after the patient has been sitting, standing, or walking for at least 2 hours, subsequently sitting for 5-15 minutes.
Patient Preparation
Ensure correct posture during collection and stable sodium intake as per guidelines.
Storage Instructions
Transport and store the specimen frozen.
Causes for Rejection
EDTA plasma is not acceptable.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 8 hours |
| Refrigerated | 5 days |
| Frozen | 1 month |
