Alpha-1-Acid Glycoprotein
Also known as: A1A GLYCO
Use
Alpha-1-Acid Glycoprotein (AAG), also known as orosomucoid, is a plasma protein produced by the liver. It is an acute phase reactant, meaning that its levels increase in response to inflammation and other physiological stresses. Clinically, measuring AAG levels can be useful for evaluating systemic inflammation and liver function. It has limited clinical utility, and its levels can be affected by a variety of conditions including inflammation, infection, malignancy, and liver disease.
Special Instructions
Patients should have blood drawn for separation within two hours of collection to ensure sample stability. The specimen should be stored in a refrigerated state and transferred promptly to an ARUP Standard Transport Tube to maintain sample integrity.
Limitations
The test may not adequately reflect local inflammatory states or predict outcomes in isolation; its interpretations must be considered in conjunction with clinical findings and other laboratory results. High levels of AAG may be seen in response to acute inflammatory stimuli but are not specific to a particular disease process. Hemolyzed specimens are unacceptable and could yield inaccurate measurements.
FDA ApprovedNew York Approved
Methodology
Immunoassay (Nephelometry)
Biomarkers
LOINC Codes
- 2685-6
Result Turnaround Time
1-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Collect whole blood in a serum separator tube or green (sodium or lithium heparin) tube. Separate serum or plasma from cells as soon as possible or within 2 hours of collection.
Storage Instructions
Refrigerated for storage and transport.
Causes for Rejection
Hemolyzed specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 8 hours |
| Refrigerated | 8 days |
| Frozen | 3 months |