Angiotensin Converting Enzyme, Serum
Also known as: ACE
Use
The measurement of angiotensin converting enzyme (ACE) activity in serum is used for the evaluation of sarcoidosis. Serum ACE activity can help assess the severity and progression of sarcoidosis in affected individuals, although it is not used to diagnose sarcoidosis alone. Elevated ACE levels may also be seen in other granulomatous diseases and certain other conditions.
Special Instructions
Measurement of ACE activity for the evaluation of sarcoidosis is not reliable when ACE inhibitors are present. Serum ACE activity is markedly reduced in patients on ACE inhibitor therapy.
Limitations
ACE activity determination may be affected by the presence of ACE inhibitors, leading to markedly reduced serum ACE levels in patients on such therapy. It is recommended to consider the patient's medication history and clinical context when interpreting results. This assay does not substitute for clinical evaluation and should not be used as the sole criterion for diagnosing or excluding sarcoidosis.
New York Approved
Methodology
Automated Analyzer (Clinical Chemistry)
Biomarkers
LOINC Codes
- 2742-5
Result Turnaround Time
1 day
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Allow specimen to clot completely at room temperature. Separate serum from cells ASAP or within 2 hours of collection.
Storage Instructions
Refrigerated.
Causes for Rejection
EDTA or heparin plasma. Hemolyzed specimens. CSF.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 1 week |
| Refrigerated | 1 week |
| Frozen | 6 months |