Antibiotic Level, Ticarcillin
Also known as: ML TICAR
Use
Ticarcillin is an antimicrobial drug, and its therapeutic monitoring is important to ensure efficacy and avoid toxicity. Monitoring the levels of ticarcillin helps in the adjustment of dosage to achieve optimal therapeutic concentrations, considering patient-specific factors such as renal function and body weight, which can affect drug clearance. It is particularly useful in managing patients with variable pharmacokinetics, such as those with renal impairment or critical illness, where standard dosing may not achieve desired drug levels.
Special Instructions
It is important to provide the time and date of collection, time of the last dose, and details of all antibiotics that the patient has received in the past 48 hours. This information is crucial for proper laboratory handling and interpretation of test results. Serum must be separated into a sterile tube and frozen immediately after collection to ensure sample integrity.
Limitations
The presence of other antimicrobial agents may interfere with the bioassay measurements, leading to inaccurate results. Furthermore, variability among patients due to differences in pharmacokinetics can affect the concentration of ticarcillin observed, such as due to renal function or interactions with other medications. The assay does not establish trough levels, and peak levels might vary based on dosage and route of administration.
New York Approved
Methodology
Other
Biomarkers
LOINC Codes
- 4054-3
Result Turnaround Time
2-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2 mL
Minimum Volume
1 mL
Container
Sterile tube (ARUP supply #43115)
Collection Instructions
Aseptically remove serum and place in a sterile tube. Freeze after collection.
Storage Instructions
Transport specimen frozen to ensure stability.
Causes for Rejection
SST or Plasma specimens are unacceptable.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 2 hours |
| Refrigerated | 24 hours |
| Frozen | 1 week |