Antimicrobial Level - Azithromycin by HPLC, Serum or Plasma
Also known as: AZITHRO
Use
This test is used for therapeutic drug monitoring to measure the level of azithromycin in the blood. It is important for ensuring that the drug concentration remains within the therapeutic range, which can help in maximizing the drug's efficacy while minimizing potential toxicity. Monitoring is particularly crucial for patients with variable drug metabolism or those receiving prolonged treatment.
Special Instructions
Patients should have their blood drawn 2-3 hours post-dose to collect peak concentrations. For those suspected of delayed drug absorption, a second specimen may be collected 4 hours after the peak. This test is not performed at ARUP; separate specimens must be submitted when multiple tests are ordered.
Limitations
The interpretation of azithromycin levels can be affected by the accuracy of the recorded time of dose and blood draw. Inaccuracies in these records can lead to incorrect interpretation of the concentration results. The methodology and performance characteristics for this test were validated by Advanced Diagnostic Laboratories at National Jewish Health but have not been cleared or approved by the U.S. Food and Drug Administration.
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 16420-2
- 48767-8
- 31208-2
Result Turnaround Time
13-17 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2 mL
Minimum Volume
0.5 mL
Container
Plain red or Green (sodium heparin)
Collection Instructions
Separate from cells ASAP or within one hour of collection. Transfer to an ARUP standard transport tube and freeze immediately.
Storage Instructions
CRITICAL FROZEN.
Causes for Rejection
Severely hemolyzed or thawed specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Unacceptable |
| Refrigerated | Unacceptable |
| Frozen | 1 month |