Antimicrobial Level - Rifabutin by HPLC, Serum or Plasma
Also known as: RIFABU
Use
This test is used to measure the level of Rifabutin in serum or plasma, which is important for monitoring therapeutic drug levels when treating mycobacterial infections. Rifabutin levels need to be within a target range to be effective without causing adverse effects. Therapeutic drug monitoring ensures the drug dosage is optimized for efficacy while minimizing toxicity.
Special Instructions
The test is not performed at ARUP Laboratories and requires separate specimen submission when multiple tests are ordered. It is performed by the National Jewish Health Advanced Diagnostic Laboratories. Special arrangements, including a Non-Permitted Laboratory Request Form, are required for New York state collections due to lack of NY state approval.
Limitations
Interpretation of results is contingent upon accurate recording of the time of the dose and the blood draw. Timing outside of recommended windows can lead to inaccuracies in determining steady-state or peak concentrations. Elevated serum concentrations can result from interactions with certain antibiotics and other medications. Data is insufficient regarding the co-administration of antacids. This assay is validated under CLIA 88 but not cleared by the FDA.
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 24032-5
- 24032-5
- 48767-8
- 31208-2
Result Turnaround Time
13-17 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2 mL
Minimum Volume
0.5 mL
Container
ARUP standard transport tube
Collection Instructions
Collect in plain red. Also acceptable: Green (sodium heparin).
Storage Instructions
CRITICAL FROZEN
Causes for Rejection
Severely hemolyzed or thawed specimens
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Unacceptable |
| Refrigerated | Unacceptable |
| Frozen | 1 month |