Antimicrobial Level - Streptomycin by HPLC, Serum or Plasma
Also known as: STREPTO
Use
This test is intended for therapeutic drug monitoring of streptomycin levels to ensure appropriate dosing for the treatment of mycobacterial infections. Monitoring streptomycin levels is crucial for ensuring therapeutic efficacy while minimizing toxicity, particularly in patients with varying renal function, which affects drug clearance. The test helps in fine-tuning the dosage to achieve therapeutic levels, especially in the context of both daily conventional dosing and high-dose regimens for specific treatment protocols.
Special Instructions
Not provided.
Limitations
The test is performed by a non-ARUP laboratory and has not been cleared or approved by the U.S. FDA. It is certified under CLIA for high complexity testing. Results are not valid for clinical diagnosis or management without considering drug administration time, renal function, and other patient-specific factors. Delayed sample collection beyond two hours post-administration may not reflect peak drug levels, leading to misinterpretation. Additionally, improper time recording of administration and collection will affect results' accuracy.
Methodology
Mass Spectrometry
Biomarkers
Streptomycin
Analyte
LOINC Codes
- 4039-4 - Streptomycin SerPl-mCnc
- 48767-8 - Annotation comment Imp
- 31208-2 - Specimen source
Result Turnaround Time
13-17 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
2 mL
Minimum Volume
0.5 mL
Container
ARUP standard transport tube
Collection Instructions
Separate from cells ASAP or within one hour of collection. Transfer to an ARUP standard transport tube.
Storage Instructions
Freeze immediately after transfer.
Causes for Rejection
Severely hemolyzed or thawed specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Unacceptable |
| Refrigerated | Unacceptable |
| Frozen | 1 month |
Other tests from different labs that may be relevant