Antimicrobial Level - Streptomycin by HPLC, Serum or Plasma

Casandra

Casandra Test Code AR70486Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 2009214CPT Code 80299

Antimicrobial Level - Streptomycin by HPLC, Serum or Plasma

Also known as: STREPTO

Clinical Use

Order Test

Use

This test is intended for therapeutic drug monitoring of streptomycin levels to ensure appropriate dosing for the treatment of mycobacterial infections. Monitoring streptomycin levels is crucial for ensuring therapeutic efficacy while minimizing toxicity, particularly in patients with varying renal function, which affects drug clearance. The test helps in fine-tuning the dosage to achieve therapeutic levels, especially in the context of both daily conventional dosing and high-dose regimens for specific treatment protocols.

Special Instructions

This test requires submission of a Non-Permitted Laboratory Request Form (NPL) to the NYDOH prior to specimen collection if intended for patients in New York state, as the test is not New York state approved. Specimens must be separated from cells ASAP and sent in a frozen state. Multiple tests require separate specimens.

Limitations

The test is performed by a non-ARUP laboratory and has not been cleared or approved by the U.S. FDA. It is certified under CLIA for high complexity testing. Results are not valid for clinical diagnosis or management without considering drug administration time, renal function, and other patient-specific factors. Delayed sample collection beyond two hours post-administration may not reflect peak drug levels, leading to misinterpretation. Additionally, improper time recording of administration and collection will affect results' accuracy.

Test Details