Antiphospholipid Syndrome Reflex Panel
Also known as: ANTI PHOS
Use
The Antiphospholipid Syndrome Reflex Panel is the preferred initial test for evaluating strongly suspected antiphospholipid syndrome (APS). APS is an autoimmune disorder associated with recurrent thrombosis and pregnancy-related complications due to the presence of antiphospholipid antibodies. The panel includes tests for Beta-2 Glycoprotein 1 Antibodies, Cardiolipin Antibodies, and the Lupus Anticoagulant Reflex Panel, which assess the presence and level of anticardiolipin antibodies and lupus anticoagulant, key laboratory criteria for the diagnosis of APS.
Special Instructions
Not provided.
Limitations
The panel has limitations in the presence of anticoagulant medications as these can interfere with the detection of lupus anticoagulant, particularly in patients undergoing heparin, direct thrombin inhibitor, or direct Xa inhibitor therapy. Variability in antibody titers over time and between different assays requires careful interpretation in the context of clinical symptoms. Testing should not occur when the patient is acutely ill or currently under anticoagulation therapy to avoid false positive results.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 75882-1 - LA 3 screen W Reflex-Imp
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
2 mL
Minimum Volume
2 mL
Container
ARUP standard transport tube
Collection Instructions
Transport 2 mL platelet poor plasma.
Causes for Rejection
Serum, EDTA plasma, clotted or hemolyzed specimens are not accepted.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 4 hours |
| Refrigerated | Unacceptable |
| Frozen | 3 months |
Other tests from different labs that may be relevant