Antiphospholipid Syndrome Reflex Panel

Casandra

Casandra Test Code AR45172Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 3017157CPT Codes 85610, 85613, 85730, 86147, 86146, 85520, 85525, 85598, 85670

Antiphospholipid Syndrome Reflex Panel

Also known as: ANTI PHOS

Clinical Use

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Use

The Antiphospholipid Syndrome Reflex Panel is the preferred initial test for evaluating strongly suspected antiphospholipid syndrome (APS). APS is an autoimmune disorder associated with recurrent thrombosis and pregnancy-related complications due to the presence of antiphospholipid antibodies. The panel includes tests for Beta-2 Glycoprotein 1 Antibodies, Cardiolipin Antibodies, and the Lupus Anticoagulant Reflex Panel, which assess the presence and level of anticardiolipin antibodies and lupus anticoagulant, key laboratory criteria for the diagnosis of APS.

Special Instructions

Ensure proper specimen collection and handling. Serum separator and sodium citrate tubes should be used, with specific transport and storage requirements for plasma and serum components. This reflex panel operates based on initial test results, which dictate subsequent reflex tests to confirm or refute APS presence.

Limitations

The panel has limitations in the presence of anticoagulant medications as these can interfere with the detection of lupus anticoagulant, particularly in patients undergoing heparin, direct thrombin inhibitor, or direct Xa inhibitor therapy. Variability in antibody titers over time and between different assays requires careful interpretation in the context of clinical symptoms. Testing should not occur when the patient is acutely ill or currently under anticoagulation therapy to avoid false positive results.

Test Details

New York Approved