Autoimmune Pediatric CNS Disorders, Serum
Also known as: AIPEDS
Use
This test is used to evaluate subacute-onset encephalopathy, epilepsy, behavioral changes, or movement disorders in individuals under 18 years of age. Testing in both serum and CSF is recommended to maximize diagnostic yield. The test is useful in diagnosing autoimmune neurologic diseases by identifying specific antibodies associated with these conditions.
Special Instructions
New York state approved. If certain antibodies (e.g., NMDA, LGI1, CASPR2, GABA-BR, MOG) are positive, reflex testing including titers and immunoblot assays may be performed. Additional charges apply for reflex tests.
Limitations
A negative test result does not rule out a diagnosis of autoimmune neurologic disease. Results should be interpreted in the context of the patient's clinical history and other laboratory findings. Serum testing should be paired with CSF testing for improved diagnostic sensitivity. The test has not been cleared or approved by the FDA.
New York Approved
Methodology
Cell-based / Cytometry (Indirect Fluorescent Antibody (IFA))
Biomarkers
LOINC Codes
- 56540-8
- 80221-5
- 61177-2
- 82979-6
- 82978-8
- 63439-4
- 82733-7
- 93428-1
- 91545-4
- 94676-4
- 101874-6
- 93498-4
Result Turnaround Time
3-10 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
3 mL
Minimum Volume
0.5 mL per aliquot
Container
Serum separator tube (SST)
Collection Instructions
Separate from cells ASAP or within 2 hours of collection. Transfer three 1 mL serum aliquots to ARUP standard transport tubes.
Storage Instructions
Frozen
Causes for Rejection
Amniotic fluid, ocular fluid, peritoneal fluid, synovial fluid, CSF, or plasma. Contaminated, hemolyzed, icteric, or lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 24 hours |
| Refrigerated | 1 week |
| Frozen | 30 days (avoid repeated freeze/thaw cycles) |