B Cell Subset Analysis
Also known as: B SUBSETS
Use
This panel identifies B-cell dysregulation, aids in diagnosing common variable immunodeficiency (CVID), and assists in predicting clinical phenotypes. It can assess B cell reconstitution post-bone marrow or hematopoietic stem cell transplantation. It is effective in identifying disorders impacting CD27+ B-cells and immunoglobulin class switching, crucial for mature B-cell development and function.
Special Instructions
Not provided.
Limitations
Reference intervals for CD20+ B-cells are not established for patients under 16. Other B-cell subsets' intervals for patients younger than 16 are literature-derived. The test is unsuitable for monitoring rituximab therapy and has specific limitations for interpreting CD20+ subsets in younger populations.
New York Approved
Methodology
Cell-based / Cytometry (Flow Cytometry)
Biomarkers
LOINC Codes
- 9558-8 - CD20 Cells # Bld
- 94689-7 - CD20 Cells/Cells.CD19 NFr Bld
- 94755-6 - CD21low38- Cells # Bld
- 94754-9 - CD21low38- Cells/Cells.CD19 NFr Bld
- 89343-8 - CD19+CD38+IgM- cells # Bld
- 89344-6 - CD38+IgM- cells/Cells.CD19 NFr Bld
- 8116-6 - CD19 Cells # Bld
- 8117-4 - CD19 Cells NFr Bld
- 89351-1 - CD19+CD27+IgD+IgM+ cells # Bld
- 89352-9 - CD27+IgD+IgM+/CD19 cells NFr Bld
- 89349-5 - CD19+CD27+IgD-IgM- cells # Bld
- 89350-3 - CD27+IgD-IgM-/CD19 cells NFr Bld
- 89353-7 - CD19+CD27+ cells # Bld
- 89358-6 - CD27 Cells/Cells.CD19 NFr Bld
- 89357-8 - CD19+CD38+IgM+ cells # Bld
- 89341-2 - CD38+IgM+ cells/Cells.CD19 NFr Bld
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
4 mL
Minimum Volume
2 mL
Container
Lavender (K2EDTA) or Pink (K2EDTA) tube
Storage Instructions
Transport specimens refrigerated
Causes for Rejection
Clotted or hemolyzed specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Unacceptable |
| Refrigerated | 48 hours |
| Frozen | Unacceptable |
Other tests from different labs that may be relevant