Bilirubin, CSF
Also known as: BILCSF
Use
The Bilirubin, CSF test is useful as an indicator of in vivo breakdown of hemoglobin to differentiate cerebral hemorrhage from a traumatic tap. It involves measuring the net absorbance of bilirubin and oxyhemoglobin in the cerebrospinal fluid (CSF) to detect subarachnoid hemorrhage.
Special Instructions
Patient preparation involves collecting the CSF ideally 12 hours after suspected hemorrhage, preferably using the last or fourth specimen post lumbar puncture. The CSF needs to be protected from light and must be centrifuged quickly. The serum sample should be allowed to clot completely and separated from cells promptly.
Limitations
The test is specifically designed to measure the net absorbance of bilirubin and oxyhemoglobin in the CSF. It has not been cleared or approved by the US Food and Drug Administration and is intended for clinical purposes within a CLIA certified laboratory. Specimens not protected from light or frozen CSF samples are unacceptable and could lead to inaccurate results.
New York Approved
Methodology
Other
Biomarkers
LOINC Codes
- 1975-2
Result Turnaround Time
1 day
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
2 mL
Minimum Volume
1 mL
Container
ARUP amber transport tube
Collection Instructions
Transport to local lab quickly and avoid pneumatic tube transport if possible. Protect from light during collection, storage, and shipment. Centrifuge for 5 minutes ASAP or within 1 hour of collection.
Patient Preparation
Collect CSF at least 12 hours after suspected hemorrhage. Use the last (ideally the fourth) specimen post lumbar puncture.
Storage Instructions
Refrigerated.
Causes for Rejection
Specimens not protected from light. Frozen CSF.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 4 hours |
| Refrigerated | 1 week |
| Frozen | Unacceptable |