C1-Esterase Inhibitor Functional
Also known as: C1 INH F
Use
This test aids in the diagnosis of hereditary angioedema (HAE) and monitors response to therapy. Abnormal concentrations of functional C1 esterase inhibitor are consistent with hereditary angioedema, and determination of these levels can help in differentiating between type I and type II HAE, as well as acquired forms of angioedema.
Special Instructions
Separate serum from cells ASAP or within 2 hours of collection. Transfer serum to ARUP Standard Transport Tube and freeze immediately. Serum Separator Tube (SST) is used for collection.
Limitations
Abnormal concentrations should be confirmed using a new specimen to rule out inactivation due to conditions of collection, transport, and handling. Normal or elevated levels do not rule out acquired forms of angioedema, as these forms may present with low C1Q concentration and/or function in addition to abnormal C1-INH concentrations.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 48494-9
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.1 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Separate from cells ASAP or within 2 hours of collection. Transfer serum to an ARUP Standard Transport Tube and freeze immediately.
Storage Instructions
CRITICAL FROZEN. Separate specimens must be submitted when multiple tests are ordered.
Causes for Rejection
Non-frozen specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 2 hours |
| Refrigerated | Unacceptable |
| Frozen | 2 weeks |