Carbamazepine Epoxide and Total
Also known as: CARB EPOXT
Use
This test is used to optimize drug therapy and monitor patient adherence by measuring carbamazepine and its active metabolite, Carbamazepine-10,11-Epoxide. It provides relevant information for therapeutic drug monitoring, particularly for patients at risk of adverse drug reactions such as Stevens-Johnson syndrome which is associated with the presence of the HLA-B*15:02 allele in certain populations.
Special Instructions
Patient preparation involves a pre-dose (trough) draw at steady-state concentration. It is critical to collect the specimen in plain red, lavender (K2 or K3EDTA), or pink (K2EDTA) tubes and separate serum or plasma from cells within 2 hours of collection.
Limitations
The therapeutic range for Carbamazepine-10,11 Epoxide is not well established. The test may not cover all potential genotypes related to carbamazepine hypersensitivity, indicating the necessity for additional pharmacogenetic testing when appropriate.
New York Approved
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 3432-2
- 9415-1
Result Turnaround Time
1-8 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Transfer serum or plasma to an ARUP Standard Transport Tube within 2 hours of collection.
Patient Preparation
Pre-dose (trough) draw at steady-state concentration is required.
Storage Instructions
Frozen; unacceptable conditions include whole blood, gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).
Causes for Rejection
Whole blood, gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 1 week |
| Frozen | 1 month |