Carbamazepine, Total (Change effective as of 10/21/24: Refer to 2011763 in the October Hotline)
Also known as: TEG
Use
Optimize drug therapy and monitor patient adherence. The test measures total carbamazepine in serum (trough) at steady-state concentration and supports therapeutic drug monitoring in light of drug‑drug interactions, protein binding displacement, and metabolism factors. It also includes interpretive insight concerning risk of Stevens‑Johnson syndrome or toxic epidermal necrolysis associated with HLA‑B*15:02 genotype. Combination with pharmacogenetic testing may benefit at-risk patients. ([ltd.aruplab.com](https://ltd.aruplab.com/Tests/Pub/0090260))
Special Instructions
Not provided.
Limitations
Cross‑reactivity with metabolites may cause differences in carbamazepine values among analytical methods. Pharmacogenetic risk (HLA‑B*15:02) requires additional testing for hypersensitivity risk. ([ltd.aruplab.com](https://ltd.aruplab.com/Tests/Pub/0090260))
New York Approved
Methodology
Immunoassay
Biomarkers
LOINC Codes
- 3432-2
Result Turnaround Time
Not provided.
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
Plain red tube
Collection Instructions
Allow specimen to clot completely at room temperature; separate serum from cells as soon as possible or within 2 hours of collection; transfer 1 mL serum to ARUP Standard Transport Tube.
Storage Instructions
Refrigerated during transport.
Causes for Rejection
Separator tubes or potassium oxalate/sodium fluoride tubes; EDTA plasma.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Ambient: 24 hours |
| Refrigerated | 7 days |
| Frozen | 1 month |