Cardiolipin Antibody, IgG
Also known as: AC-IGG
Use
The test is used as a laboratory criterion for diagnosing antiphospholipid syndrome (APS) by detecting the persistent presence of cardiolipin antibodies in moderate or high levels. These antibodies, in levels greater than 40 GPL for IgG and/or greater than 40 MPL for IgM, must be confirmed by two or more specimens drawn at least 12 weeks apart. Lower positive levels (above cutoff but less than 40 GPL/MPL) can occur in patients with APS symptoms, though their actual significance is uncertain. Results should be interpreted alongside clinical APS manifestations and other phospholipid antibody tests.
Special Instructions
Ensure to order with Lupus Anticoagulant Reflex Panel and Beta-2 Glycoprotein 1 Antibodies for comprehensive APS assessment. Cardiolipin Antibodies, IgG and IgM (0099344) is the preferred test for a complete profile.
Limitations
The persistence of cardiolipin antibodies in levels below 40 GPL/MPL cannot definitively diagnose APS, as results need corroboration with clinical symptoms and other specific antibody tests. The exact significance of lower positive levels remains undefined, and results should not be solely used for APS diagnosis.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 3181-5
Result Turnaround Time
1-2 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.3 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Separate serum from cells ASAP or within 2 hours of collection.
Storage Instructions
Refrigerated transport.
Causes for Rejection
Plasma or other body fluids, contaminated, heat-inactivated, hemolyzed, or lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year |