CD22 by Immunohistochemistry
Also known as: CD22IHC
Use
The CD22 by Immunohistochemistry test is used for the detection of CD22 protein expression in tissues. It is primarily utilized in the diagnostic evaluation of B-cell related malignancies, such as various types of lymphoma. CD22 is a surface antigen found on mature B-cells and is useful in distinguishing B-cell lymphomas from other types of lymphoid or non-lymphoid malignancies. The test aids pathologists and oncologists in the identification and classification of hematologic neoplasms based on the immunophenotypic profile.
Special Instructions
This test is offered as a stain and return (technical) service only. Electronic request submission is preferred, but if you lack electronic ordering capability, use the ARUP Immunohistochemistry Stain Form with an ARUP client number. Protect specimens from excessive heat and transport in a Tissue Transport Kit. The paraffin block or slides should be stored at room temperature or refrigerated and shipped in a cooled container during summer months.
Limitations
This test is limited by the quality and representativeness of the submitted tissue sample. Nonrepresentative tissue or depleted specimens are unacceptable. Interpretive results rely on the quality of the staining and the experience of the interpreting pathologist. It is crucial that slides are neither overly dried nor improperly fixed, as these conditions can lead to suboptimal staining and potentially erroneous interpretation. Furthermore, as a laboratory developed test, it is not FDA-approved, although it is New York State approved.
New York Approved
Methodology
Immunoassay (IHC)
Biomarkers
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Tissue (FFPE)
Volume
Not provided
Minimum Volume
Not provided
Container
Tissue Transport Kit (ARUP supply #47808)
Collection Instructions
Collect tissue or cells. Formalin fix (10 percent neutral buffered formalin) and paraffin embed specimen. Protect paraffin block and/or slides from excessive heat.
Storage Instructions
Room temperature; acceptable refrigerated. Ship in cooled container during summer months.
Causes for Rejection
Nonrepresentative tissue type, depleted specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Indefinitely |
| Refrigerated | Indefinitely |
| Frozen | Unacceptable |