CD4+ T-Cell Recent Thymic Emigrants (RTEs)
Also known as: CD4 RTE
Use
The CD4+ T-Cell Recent Thymic Emigrants (RTEs) test is used to assess thymic function in suspected cases of severe combined immunodeficiency (SCID), DiGeorge syndrome, and other T-cell immune deficiency disorders. It is also used to evaluate immune reconstitution during highly active antiviral therapy (HAART) in HIV patients, as well as post-chemotherapy and after hematopoietic cell transplants. Recent thymic emigrants (RTEs) are measured as a percent of CD4+ T-cells, representing naive T-cells that have recently migrated from the thymus. Decreased or absent RTEs are associated with reduced or impaired thymic output.
Special Instructions
Not provided.
Limitations
RTE results should be interpreted with caution in adults due to age-related decline in thymic function. The test must be performed in a CLIA certified laboratory and is not cleared or approved by the US FDA. Specimens older than the specified stability times (48 or 72 hours, depending on location) or that are clotted, hemolyzed, or cord blood are unacceptable.
Methodology
Cell-based / Cytometry (Flow Cytometry)
Biomarkers
Abs CD4+CD31+CD45RA+ (RTEs)
Cell TypeCD4+CD31+CD45RA+ (RTEs)
Cell Type
LOINC Codes
- 24467-3 - CD3+CD4+ Cells # Bld
- 8123-2 - CD3+CD4+ Cells NFr Bld
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
4 mL
Minimum Volume
0.5 mL
Container
Lavender (EDTA) or green (sodium or lithium heparin)
Storage Instructions
Refrigerated or room temperature storage acceptable. New York State clients should preferably send at room temperature.
Causes for Rejection
Cord blood, specimens older than 72 hours, clotted or hemolyzed specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 72 hours |
| Frozen | Unacceptable |
Other tests from different labs that may be relevant