Chromosome Analysis, Amniotic Fluid
Also known as: CHR AF
Use
Prenatal chromosome analysis on amniotic fluid is utilized for individuals at increased risk for fetal aneuploidy due to factors such as advanced maternal age, abnormal noninvasive prenatal testing (NIPT), abnormal multiple marker screening, or abnormal fetal ultrasound results. It is also applicable for cases with a family history of chromosomal abnormalities or genetic disorders, or when diagnostic testing is preferred over screening.
Special Instructions
This test requires a Prenatal Cytogenetics Patient History Form and informed consent, particularly for patients in New York. Specimen and completed test request form, including the clinical indication, must be received within 48 hours to ensure proper processing.
Limitations
The standard cytogenetic methodology used in this analysis may not detect small rearrangements or low-level mosaicism and cannot detect submicroscopic deletions or duplications detectable by genomic microarray analysis. Results can be compromised if the specimen integrity is inadequate to grow cultures.
New York Approved
Methodology
Chromosomal / Cytogenetics (G-Banding)
Biomarkers
LOINC Codes
- 33773-3
- 11526-1
Result Turnaround Time
7-14 days
Related Documents
For more information, please review the documents below
Specimen
Amniotic Fluid
Volume
30 mL
Minimum Volume
15 mL
Container
Sterile container
Storage Instructions
Transport at room temperature. Do not freeze or expose to extreme temperatures.
Causes for Rejection
Frozen specimens; Bloody specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 48 hours |
| Frozen | Unacceptable |