Chromosome Analysis, Chorionic Villi
Also known as: CHR CVS
Use
This test is used for prenatal chromosome analysis on chorionic villi. It is indicated for individuals at increased risk for fetal aneuploidy due to factors such as maternal age, abnormal noninvasive prenatal testing (NIPT), abnormal multiple marker screening, abnormal fetal ultrasound, family history of chromosome abnormalities, or genetic disorders. It is also suitable for those seeking diagnostic testing instead of screening.
Special Instructions
Chorionic villus samples must be collected in a sterile, screw-top container with tissue culture transport medium. Ensure that the media is thawed prior to collection, and that the specimen is kept at room temperature. Do not freeze or use formalin for preservation. New York clients must include informed consent with specimen submission, and provide clinical indication or reason for testing alongside specimen type.
Limitations
The Giemsa Band methodology used in this analysis may not detect small rearrangements, low-level mosaicism, or submicroscopic deletions/duplications detectable by genomic microarray. The karyotype obtained from chorionic villus samples may not always accurately reflect the fetal chromosome complement due to rare discordances.
New York Approved
Methodology
Chromosomal / Cytogenetics (Giemsa Band)
Biomarkers
LOINC Codes
- 33774-1
- 11502-2
Result Turnaround Time
7-14 days
Related Documents
For more information, please review the documents below
Specimen
Tissue
Volume
Not provided
Minimum Volume
Not provided
Container
Sterile screw-top container filled with tissue culture transport medium
Collection Instructions
Thaw media prior to collection. Do not freeze. Ensure sample is not placed in formalin and is transported at room temperature.
Storage Instructions
Room temperature transport
Causes for Rejection
Frozen specimens or those preserved in formalin
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 48 hours |
| Frozen | Unacceptable |