Chromosome Analysis, Lymph Node
Also known as: CHR ONC
Use
Chromosome analysis on lymph node biopsies can provide valuable information for the diagnosis and management of lymphomas. It helps in detecting clonal chromosomal abnormalities, which may indicate the presence of diseases such as diffuse large B-cell lymphoma or other B-cell lymphoproliferative disorders. Detection of specific chromosomal translocations and trisomies can assist in identifying the underlying genetic alterations and guide treatment strategies.
Special Instructions
This test must be ordered using Oncology test request form #43099 or through your ARUP interface. A processing fee will be charged if this procedure is canceled after the test has been set up or if the specimen integrity is inadequate for culture growth. Indicate if patient has received a bone marrow transplant and specify sex of donor.
Limitations
As this analysis involves culturing living cells, various factors can affect turnaround time. Frozen specimens and lymph nodes placed in formalin are unacceptable because they compromise cell viability and culturing ability. Appropriate culturing and reporting may be delayed if clinical indication or reason for testing and specimen type are not provided at order submission.
Methodology
Chromosomal / Cytogenetics (Karyotype)
Biomarkers
LOINC Codes
- 62357-9
Result Turnaround Time
3-10 days
Related Documents
For more information, please review the documents below
Specimen
Tissue
Volume
Not provided
Minimum Volume
10 mm biopsy
Container
Sterile, screw-top container filled with tissue culture transport media
Collection Instructions
Thaw media prior to tissue inoculation. Collect lymph node biopsy in a sterile, screw-top container filled with tissue culture transport medium.
Storage Instructions
Transport at room temperature.
Causes for Rejection
Frozen specimens. Lymph node submitted in formalin.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 48 hours |
| Frozen | Unacceptable |
