Chromosome Analysis, Solid Tumor
Also known as: CHR ST
Use
Chromosome Analysis, Solid Tumor is used to identify cytogenetic abnormalities in solid tumor tissues, particularly those not targeted by FISH assays. This can be crucial for understanding tumor progression and selecting treatment options, as it may reveal additional chromosomal anomalies that are not detectable with other methodologies. For lymph node samples, a separate test is recommended as per the guidelines.
Special Instructions
It is crucial to collect a solid tumor tissue biopsy in a sterile, screw-top container filled with tissue culture transport medium. Ensure that the media is thawed prior to tissue inoculation. Do not freeze the specimen or place it in formalin as this can compromise the sample. A processing fee will apply if the procedure is canceled after setup or if the specimen integrity is inadequate. Ensure to indicate if the patient has received bone marrow transplant and specify the donor's sex. This test must be ordered using Oncology test request form #43099 or through ARUP interface.
Limitations
The methodology involves culturing of living cells, hence the turnaround time is subject to variability due to factors affecting cell growth. The procedure might have delayed or compromised results if information such as clinical indication and specimen type is not provided, although the sample will still be processed. Additionally, the use of formalin-preserved or frozen specimens will result in rejection of the sample.
New York Approved
Methodology
Chromosomal / Cytogenetics (Karyotype)
Biomarkers
Result Turnaround Time
14-28 days
Related Documents
For more information, please review the documents below
Specimen
Tumor Tissue (Unknown)
Volume
10 mm solid tumor tissue biopsy
Minimum Volume
5 mm solid tumor tissue biopsy
Container
sterile, screw-top container with tissue culture transport medium
Collection Instructions
Thaw media prior to tissue inoculation. Collect the biopsy in a sterile container filled with tissue culture transport medium.
Storage Instructions
Transport at room temperature.
Causes for Rejection
Frozen specimens. Specimens preserved in formalin.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 48 hours |
| Frozen | Unacceptable |