Chymotrypsin, Fecal
Also known as: CHYMOTRYP
Use
The Chymotrypsin, Fecal test is used to assess pancreatic function by measuring the level of chymotrypsin enzyme in stool. It is a key test in evaluating patients for chronic pancreatitis and other conditions related to the exocrine pancreatic function. Low levels of chymotrypsin in feces may indicate pancreatic insufficiency, which can be seen in conditions like chronic pancreatitis, cystic fibrosis, and pancreatic cancer.
Special Instructions
Patients receiving pancreatic enzyme replacement therapy should discontinue taking these enzymes at least 5 days before collecting stool samples to avoid inaccurate results. The test is not performed at ARUP Laboratories, and separate specimens must be submitted if additional tests are ordered.
Limitations
This test is performed by an external laboratory, specifically Quest Diagnostics. Despite having been validated according to CLIA regulations for clinical purposes, it has not been cleared or approved by the FDA. This poses a limitation in the regulatory acceptance of the results. The stability of the specimen is also a limiting factor; it remains stable for 2 weeks when refrigerated and for 1 month when frozen, but it is unsuitable for testing if kept at ambient temperature.
New York Approved
Methodology
Other
Biomarkers
LOINC Codes
- 25375-7
Result Turnaround Time
8-14 days
Related Documents
For more information, please review the documents below
Specimen
Stool
Volume
1 g
Minimum Volume
0.5 g
Container
Clean, unpreserved stool transport vial
Collection Instructions
Transfer 1 g stool to a clean, unpreserved stool transport vial. ARUP Supply #40910 can be obtained online through eSupply using ARUP Connect or by contacting ARUP Client Services.
Patient Preparation
Discontinue pancreatic enzyme supplements at least 5 days prior to stool collection.
Storage Instructions
Store the specimen frozen; refrigeration is also acceptable.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Unacceptable |
| Refrigerated | 2 weeks |
| Frozen | 1 month |