Circulating Immune Complex, C1q Binding
Also known as: C1Q
Use
This test is used to detect circulating immune complexes, which are involved in a variety of immune-mediated disorders such as systemic lupus erythematosus. The presence of these complexes in the blood can imply an ongoing immune response or inflammation. Clinical interpretation should consider that these complexes can be present without any evident pathology and a positive result does not necessarily indicate a direct role of the immune complexes in any disease process.
Special Instructions
Ensure specimens are frozen immediately after separating serum from cells to preserve sample integrity. The test requires specific storage conditions and handling due to the critical frozen requirement. When ordering in conjunction with other related tests, ensure separate serum aliquots are submitted to prevent reactivity due to sample handling.
Limitations
The test is semi-quantitative and outcomes can be affected by improper sample handling, such as repeated freeze/thaw cycles or the presence of autoantibodies to C1q, which may produce false results. The presence of aggregates other than CICs can confound interpretation. Positive results should be confirmed with clinical correlation, as they do not necessarily indicate pathology.
New York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 27831-7
Result Turnaround Time
2-9 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.3 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Collect blood in plain red or serum separator tube. Allow complete clotting of red blood cells, separate serum from cells and freeze immediately.
Storage Instructions
CRITICAL FROZEN. Separate specimens must be submitted for multiple tests.
Causes for Rejection
Non-frozen specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 2 hours |
| Refrigerated | Unacceptable |
| Frozen | 2 weeks |