Clomipramine and Metabolite, Serum or Plasma
Also known as: CLOMIP
Use
This test is used to optimize dosing and monitor patient adherence to clomipramine therapy, especially concerning its antidepressant characteristics. The therapeutic range helps in assessing the efficacy of the drug in alleviating depressive symptoms, although a therapeutic range for treating obsessive-compulsive disorder is not well established. Monitoring clomipramine levels is crucial given the potential toxic effects, such as anticholinergic effects, CNS depression, cardiac abnormalities, seizures, and hypotension, which can occur at higher concentrations.
Special Instructions
Specimen collection should be done as a predose (trough) draw at steady-state concentration. It is important to separate serum or plasma from cells within two hours of collection and transfer to an ARUP standard transport tube for accurate analysis. Test is approved for use in New York.
Limitations
Toxic concentrations of clomipramine can result in significant clinical effects, making the monitoring of levels critical. The therapeutic ranges pertain to depression treatment, and there is no well-established range for obsessive-compulsive disorder, which may limit its interpretive use in this context.
New York Approved
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 3491-8
- 3493-4
- 3536-0
Result Turnaround Time
2-8 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP standard transport tube
Collection Instructions
Separate serum or plasma from cells within 2 hours of collection.
Patient Preparation
Timing of specimen collection: Predose (trough) draw at steady-state concentration.
Storage Instructions
Refrigerated.
Causes for Rejection
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 5 days |
| Refrigerated | 2 weeks |
| Frozen | 6 months |