Clozapine and Metabolites, Serum or Plasma, Quantitative
Also known as: CLOZAP SP
Use
This test is used to optimize drug therapy and monitor patient adherence by measuring the levels of clozapine and its metabolites in the serum or plasma. It is particularly useful in determining therapeutic response and assessing potential toxicity. Clozapine is an antipsychotic used in the treatment of schizophrenia, and monitoring its levels helps in managing and adjusting dosages for therapeutic efficacy and minimizing side effects.
Special Instructions
Not provided.
Limitations
Therapeutic and toxic ranges are not well established in children. Clozapine concentrations between 100 and 700 ng/mL may not correlate with clinical response, and non-responsiveness can occur within this range. The test has not been cleared or approved by the US Food and Drug Administration, and performance characteristics have been determined by ARUP Laboratories.
New York Approved
Methodology
Mass Spectrometry
Biomarkers
Clozapine
AnalyteClozapine-N-Oxide
AnalyteNorclozapine
Analyte
LOINC Codes
- 12375-2 - cloZAPine+Nor SerPl-mCnc
- 6896-5 - cloZAPine SerPl-mCnc
- 10992-6 - Norclozapine SerPl-mCnc
- 85497-6 - CNO SerPl-mCnc
Result Turnaround Time
1-5 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP standard transport tube
Collection Instructions
Separate serum or plasma from cells within 2 hours of collection.
Patient Preparation
Predose (trough) draw at steady-state concentration.
Storage Instructions
Refrigerated.
Causes for Rejection
Whole blood. Gel separator tubes, light blue (citrate), or yellow (SPS or ACD solution).
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 24 hours |
| Refrigerated | 1 week |
| Frozen | 3 months |
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