Cobalt, Urine
Also known as: COBALT U
Use
Urine cobalt levels can be used to monitor acute exposure as the reported half-life of cobalt is on the order of several days. Urine cobalt levels generally do not exceed 1.0 ug/L in the general population and are rarely used in the management of chronic exposure. Symptoms associated with cobalt toxicity vary based upon route of exposure and may include cardiomyopathy, allergic dermatitis, pulmonary fibrosis, cough, and dyspnea.
Special Instructions
Diet, medication, and nutritional supplements may introduce interfering substances. Patients should discontinue nutritional supplements, vitamins, minerals, and nonessential over-the-counter medications upon physician's advice. High concentrations of iodine may interfere with elemental testing. Collection from patients receiving iodinated or gadolinium-based contrast media should be avoided for a minimum of 72 hours post-exposure. Collection from patients with impaired kidney function should be avoided for a minimum of 14 days post-contrast media exposure.
Limitations
Elevated results may be due to skin or collection-related contamination, including the use of collection containers that are not certified to be trace element-free. If an elevated result is suspected to be due to contamination, confirmation with a second specimen collected in a certified trace element-free container is recommended. Per 24h calculations are provided to aid interpretation for collections with a duration of 24 hours and an average daily urine volume. For specimens with notable deviations in collection time or volume, ratios of analytes to a corresponding urine creatinine concentration may assist in result interpretation.
New York Approved
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 19153-6
- 30211-7
- 35674-1
- 2162-6
- 21208-4
- 29916-4
- 29934-7
- 19153-6
- 30211-7
- 35674-1
- 2162-6
- 21208-4
- 29916-4
- 29934-7
Result Turnaround Time
1-5 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
8 mL
Minimum Volume
1 mL
Container
Plastic container, ARUP Trace Element-Free Transport Tubes
Collection Instructions
24-hour urine. Refrigerate during collection. Specimen must be collected in a plastic container. Record total volume and collection time interval on transport tube and on test request form.
Storage Instructions
Refrigerated. Also acceptable: Room temperature or frozen.
Causes for Rejection
Specimens collected within 72 hours after administration of iodinated or gadolinium-based contrast media. Acid preserved urine. Specimens transported in containers other than specified. Specimens contaminated with blood or fecal material.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 1 week |
| Refrigerated | 2 weeks |
| Frozen | 1 year |