Complement C5, Functional
Also known as: C5 FUNCT
Use
The Complement C5, Functional test aids in the diagnosis of C5 deficiency by investigating abnormal total complement activity. This can assist in identifying inherited or acquired deficiencies of the C5 component, which is an essential part of the immune system. The test may also be used to assess response to anticomplement therapeutics and to investigate low C5 functional activity accompanied by low C5 concentrations. The normal range of C5 functional activity suggests sufficient C5 protein levels and functionality.
Special Instructions
Critical frozen specimens must be submitted for this test. Specimen should be clotted at room temperature for one hour, and serum should be separated from cells as soon as possible or within two hours of collection. Serum should be transferred to an ARUP standard transport tube. Separate specimens must be sent when multiple tests are ordered.
Limitations
The test may not be suitable for samples that are grossly hemolyzed or severely lipemic. Samples left to clot at 2-8 degrees Celsius, specimens exposed to repeated freeze/thaw cycles, nonfrozen specimens, and those collected in separator tubes are unacceptable. The performance characteristics have been determined by ARUP Laboratories and the test is intended for clinical purposes, but it has not been cleared or approved by the FDA.
New York Approved
Methodology
Immunoassay (Other)
Biomarkers
LOINC Codes
- 60472-8
- 60472-8
Result Turnaround Time
1-7 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP standard transport tube
Collection Instructions
Allow specimen to clot for one hour at room temperature. Separate serum from cells ASAP or within two hours of collection. Transfer 1 mL serum to an ARUP standard transport tube. Separate specimens must be submitted when multiple tests are ordered.
Causes for Rejection
Separator tubes, specimens left to clot at 2-8 degrees C, specimens exposed to repeated freeze/thaw cycles, nonfrozen specimens, grossly hemolyzed or severely lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Unacceptable |
| Refrigerated | 8 days |
| Frozen | 1 month |