Complement Component 3
Also known as: C3
Use
The Complement Component 3 (C3) test is crucial in evaluating patients suspected of having complement deficiencies, which can lead to recurrent infections and autoimmune diseases. The measurement of C3 levels helps in diagnosing conditions related to the immune system, particularly those involving the complement system, such as systemic lupus erythematosus (SLE) and other forms of inherited or acquired complement deficiencies. This test is useful in ruling out a deficiency in this crucial component of the complement system which plays a vital role in the body's defense against pathogens.
Special Instructions
Ensure proper specimen handling by collecting in a serum separator tube or plasma separator tube, and processing the specimen within two hours to avoid degradation. The specimen should be transferred to an ARUP Standard Transport Tube and frozen according to the instructions to maintain integrity. Avoid using specimens that have undergone repeated freeze/thaw cycles or were clotted at refrigerated temperatures.
Limitations
The Complement Component 3 test may have limitations in cases where there is insufficient specimen volume or improper handling, such as exposure to freeze/thaw cycles, which can affect the accuracy of the results. Additionally, certain medications or medical conditions not related to complement deficiencies could potentially alter complement protein levels, leading to inaccurate diagnostic conclusions. The test is specific for C3 complement and may not provide information on other components of the complement system. Reference intervals may vary based on age, and it is important to compare results against age-specific ranges provided.
FDA ApprovedNew York Approved
Methodology
Immunoassay (Quantitative Immunoturbidimetry)
Biomarkers
LOINC Codes
- 4485-9
Result Turnaround Time
1 day
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
0.5 mL
Minimum Volume
0.3 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Allow specimen to clot at room temperature. Separate from cells ASAP or within 2 hours of collection. Transfer to transport tube and freeze.
Storage Instructions
Frozen
Causes for Rejection
Specimens left to clot at refrigerated temperature. Specimens exposed to repeated freeze/thaw cycles.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 4 days |
| Refrigerated | 8 days |
| Frozen | 2 weeks |