Cryofibrinogen
Also known as: CRYO FIB
Use
This test aids in the evaluation of patients with vasculitis, macroglobulinemia, or multiple myeloma, particularly those experiencing symptoms exacerbated by cold exposure. Detecting cryofibrinogen can help diagnose conditions where symptoms are triggered or worsened by cold temperatures, assisting healthcare providers in developing appropriate management strategies.
Special Instructions
Proper collection and transport of the specimen is critical for accurate assay outcomes. Patients must provide a fasting specimen collected in a prewarmed syringe and maintained at 37 degrees Celsius throughout processing. Room temperature or refrigerated specimens are acceptable for transport, but serum, heparinized plasma, or grossly hemolyzed/lipemic specimens will be rejected.
Limitations
Quantities of plasma less than 3 mL may reduce the assay's sensitivity. Specimens should neither be refrigerated nor frozen at any point prior to testing, as temperature fluctuations can affect cryoprecipitate formation and potentially lead to false-negative results. The qualitative nature of this test limits its ability to provide quantitative cryofibrinogen levels.
New York Approved
Methodology
Other
Biomarkers
LOINC Codes
- 29744-0
Result Turnaround Time
3-5 days
Related Documents
For more information, please review the documents below
Specimen
Plasma
Volume
3 mL
Minimum Volume
1 mL
Container
Blue (sodium citrate) or black (sodium citrate) tube
Collection Instructions
Collect whole blood in prewarmed syringe, transfer immediately to prewarmed citrate tube. Maintain at 37°C; do not refrigerate or freeze.
Patient Preparation
Fasting specimen required: Overnight or minimum of 8 hours fasting.
Storage Instructions
Room temperature; refrigerated acceptable for transport.
Causes for Rejection
Serum, heparinized plasma, gross hemolysis or lipemia.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 1 week |
| Refrigerated | 1 week |
| Frozen | Unacceptable |