Cytogenomic SNP Microarray - Oncology
Also known as: CMA ONC
Use
This test is primarily used for detecting clinically significant genomic abnormalities in leukemias, lymphomas, and solid tumors, particularly those involving DNA loss/gain or loss of heterozygosity (LOH). It is a preferred choice for fresh specimens at the time of diagnosis, as it aids in monitoring disease progression and response to therapy.
Special Instructions
This test must be ordered using a Cytogenetic test request form 43099 or through the ARUP interface.
Limitations
The test cannot provide structural or positional information associated with genomic imbalance, hence additional cytogenetic testing by chromosome analysis or FISH may be recommended. Low-level mosaicism, sequence-level variants, and certain balanced chromosomal rearrangements may not be detected. CNVs below the platform's resolution limit and genomic imbalances in repetitive DNA regions may also go undetected.
Methodology
Microarray
Biomarkers
Result Turnaround Time
10-14 days
Related Documents
For more information, please review the documents below
Specimen
Bone Marrow
Volume
3 mL
Minimum Volume
1 mL
Container
Green (sodium heparin)
Storage Instructions
Room temperature
Causes for Rejection
Frozen specimens; Clotted specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 48 hours |
| Frozen | Unacceptable |