Deoxypyridinoline Crosslinks, Urine
Also known as: DPD
Use
Deoxypyridinoline (DPD) is a crosslink of type I collagen found in bone and is released during bone resorption into urine. This test measures the level of deoxypyridinoline in urine, which is a biochemical marker for bone resorption. It is useful in the management of patients with metabolic bone diseases such as osteoporosis, allowing clinicians to assess the effectiveness of anti-resorptive therapies and monitor bone turnover rate changes over time.
Special Instructions
First-morning void collection is preferred for accurate assessment. Specimen should be transferred into the ARUP Standard Transport Tube as per the guidelines to ensure proper handling and transport conditions.
Limitations
Certain factors can influence the urine concentration of DPD, such as renal function and hydration status, potentially affecting the test's accuracy. This test should not be used as a sole diagnostic tool for osteoporosis or other bone disorders but rather as a complementary assessment to clinical findings and other diagnostic tests.
FDA ApprovedNew York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 25095-1
- 35674-1
Result Turnaround Time
1-8 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
3.5 mL
Minimum Volume
0.5 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Transfer 3.5 mL aliquot from a well-mixed, first-morning urine to the ARUP Standard Transport Tube.
Patient Preparation
First-morning void.
Storage Instructions
Frozen.
Causes for Rejection
Urine not collected or stored as specified.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 2 hours |
| Refrigerated | 1 week |
| Frozen | 3 months |