DNA Cell Cycle Analysis - Ploidy and S-Phase

Casandra

Casandra Test Code AR44445Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 0095155CPT Code 88182

DNA Cell Cycle Analysis - Ploidy and S-Phase

Also known as: DNA MISC

Clinical Use

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Use

The DNA Cell Cycle Analysis - Ploidy and S-Phase test assists in evaluating the prognosis of malignancy across various tumor specimen types. The analysis provides insights into tumor DNA content which is diagnostically and prognostically significant depending on the tumor type and tissue source. It is particularly valuable in understanding disease-free survival rates and treatment sensitivity in conditions like acute lymphoblastic leukemia (ALL), especially in pediatric patients where the DNA index indicates remission and sensitivity to antimetabolites.

Special Instructions

The test is suitable for all tumor tissue specimens except products of conception. For such specimens, a different test should be used. Specimens from New York clients will be sent to a New York state-approved laboratory. A Pathologist Block Selection Fee will be added for orders requesting ARUP pathologist's discretion in choosing the specimen most appropriate for testing when multiple specimens are sent without specific instructions.

Limitations

Specimens fixed in certain solutions such as Bouin's solution, mercuric chloride containing fixatives, or ethanol-based fixatives are not acceptable. Also, clotted or hemolyzed blood or bone marrow and decalcified specimens will be rejected. The test does not include specific interpretive information for all tumor types, and the diagnostic and prognostic importance may vary based on the source tissue and type of tumor. The S-Phase information may not be separately available for certain diploid and hypodiploid tumors.

Test Details