DNase-B Antibody
Also known as: DNSB
Use
The DNase-B Antibody test is used to confirm current or recent infections with group A Streptococcus in patients suspected of having nonsuppurative complications such as acute glomerulonephritis (AGN) or acute rheumatic fever (ARF). Elevated titers of antideoxyribonuclease B antibody indicate recent infections. It is the preferred test for diagnosing rheumatic chorea, as it remains elevated longer than ASO antibody titers.
Special Instructions
Not provided.
Limitations
Negative or very low anti-DNase B and ASO antibody titers, especially from a specimen tested two weeks after a suspected infection, suggest that a recent Streptococcus infection is unlikely. This test must be ordered in conjunction with a clinical evaluation, especially in individuals suspected of having complications related to Streptococcus infection.
New York Approved
Methodology
Automated Analyzer (Clinical Chemistry)
Biomarkers
LOINC Codes
- 5133-4
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.4 mL
Container
Serum separator tube
Collection Instructions
Separate serum from cells ASAP or within 2 hours of collection. Transfer serum to an ARUP standard transport tube.
Causes for Rejection
Plasma or severely hemolyzed specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 2 hours |
| Refrigerated | 8 days |
| Frozen | 3 months |