Fungal Antibodies with Reflex to Blastomyces dermatitidis Antibodies by Immunodiffusion, CSF
Also known as: FUNG R CSF
Use
This test is designed to detect antibodies to Aspergillus, Coccidioides, and Histoplasma by complement fixation and Blastomyces by immunoassay in cerebrospinal fluid (CSF). It aids in the evaluation of fungal infection in the central nervous system but is not recommended as a primary diagnostic tool for such infections. The presence of antibodies is suggestive of infection or exposure, but cross-reactions may occur. If Blastomyces antibodies are equivocal or positive by immunoassay, further confirmation is done with immunodiffusion.
Special Instructions
Not provided.
Limitations
These tests are not cleared or approved by the US Food and Drug Administration. Antibody detection can vary based on disease state and prior treatments. Titers in complement fixation may not correlate with active infection in all cases due to the potential for cross-reactions, especially with dimorphic fungi in the Aspergillus genus. Negative results do not necessarily rule out infection, especially in cases of chronic fungal disease or immunocompromised patients.
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 13201-9 - B dermat Ab CSF-aCnc
- 13917-0 - C immitis Ab Titr CSF CF
- 23953-3 - Aspergillus Ab Titr CSF CF
- 27209-6 - H capsul Yst Ab Titr CSF CF
- 27220-3 - H capsul Myc Ab Titr CSF CF
- 13917-0 - C immitis Ab Titr CSF CF
- 23953-3 - Aspergillus Ab Titr CSF CF
- 27220-3 - H capsul Myc Ab Titr CSF CF
- 27209-6 - H capsul Yst Ab Titr CSF CF
- 13201-9 - B dermat Ab CSF-aCnc
Result Turnaround Time
2-6 days
Related Documents
For more information, please review the documents below
Specimen
Cerebrospinal Fluid
Volume
2 mL
Minimum Volume
1 mL
Container
ARUP standard transport tube
Causes for Rejection
Other body fluids. Contaminated, hemolyzed, xanthochromic, or severely lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 1 year (avoid repeated freeze/thaw cycles) |
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