Glomerular Basement Membrane Antibody, IgG (IFA)

Casandra

Casandra Test Code AR80244Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 0049191CPT Code 86255

Glomerular Basement Membrane Antibody, IgG (IFA)

Also known as: GBM-G IFA

Clinical Use

Order Test

Use

The Glomerular Basement Membrane Antibody, IgG (IFA) test is used to detect antibodies against the glomerular basement membrane (GBM) antigen, which can be indicative of Goodpasture syndrome. The presence of these antibodies detected by either indirect fluorescent antibody (IFA) or multiplex bead assay can support the diagnosis of the disease. These antibodies are associated with autoimmune kidney diseases and their detection can be useful for monitoring treatment response when combined with other assays.

Special Instructions

It is recommended to combine the use of IFA Glomerular Basement Membrane Antibody, IgG with the Multiplex Bead Assay to improve diagnostic sensitivity. A positive result should be confirmed by a renal biopsy. The sample should be separated from cells within 2 hours of collection and transported refrigerated to maintain stability. Avoid repeated freeze/thaw cycles.

Limitations

This test was developed and its performance characteristics determined by ARUP Laboratories. It has not been cleared or approved by the US Food and Drug Administration, and is performed in a CLIA certified laboratory intended for clinical purposes. The combined use of multiple assays increases diagnostic sensitivity, and a positive result should be corroborated with a renal biopsy. Assay performance and diagnostic accuracy may vary, and results should be interpreted in context with clinical findings.

Test Details

New York Approved