Glutamic Acid Decarboxylase Antibody
Use
Most useful to establish autoimmune etiology in previously diagnosed type 1 diabetes mellitus (DM). This test should not be used to differentiate type 1 DM from type 2 DM, for most cases. It is recommended to perform at least two antibody tests to determine autoimmune DM, with the glutamic acid decarboxylase antibody being one of the options. Other complementary tests include Islet Antigen-2 (IA-2) Autoantibody, Insulin Antibody, Islet Cell Cytoplasmic Antibody, IgG, and Zinc Transporter 8 Antibody.
Special Instructions
For analysis in CSF, refer to Glutamic Acid Decarboxylase Antibody, CSF. Notably, New York state approval has been obtained for this test. It is recommended to combine it with another antibody test for comprehensive results.
Limitations
This assay is designed for the semi-quantitative determination of the glutamic acid decarboxylase antibody in human serum. Results should be interpreted within the context of clinical symptoms. Plasma and grossly hemolyzed specimens are unacceptable for this test, which undermines its reliability in such conditions.
FDA ApprovedNew York Approved
Methodology
Immunoassay (ELISA)
Biomarkers
LOINC Codes
- 56540-8
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Collect using a serum separator tube.
Storage Instructions
Frozen storage/transport is required.
Causes for Rejection
Plasma and grossly hemolyzed specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 24 hours |
| Refrigerated | 1 week |
| Frozen | 3 months |