Growth Hormone, Timed - Other

Casandra

Casandra Test Code AR49897Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 0070069CPT Code 83003

Growth Hormone, Timed - Other

Also known as: GH OTHER

Clinical Use

Order Test

Use

For pediatric patients, very low peak growth hormone (GH) concentrations on stimulation testing are consistent with severe GH deficiency (GHD). Thresholds distinguishing normal from partial GHD have not been well established. Inadequate response to two different provocative tests is required for diagnosis of GHD. In adults, expected peak GH concentrations depend on the stimulation test performed, as described in Endocrine Society guidelines for the evaluation and treatment of adults with GHD. For suppression testing, healthy subjects have GH concentrations of less than 1 ng/mL within 2 hours of ingestion of a glucose dose. Patients with acromegaly fail to show normal suppression.

Special Instructions

This Growth Hormone assay is standardized to the Recombinant Second International Standard (IS): 98/574. Growth hormone results read approximately 25 percent lower than with the previous standards. Reference ranges have been modified according to the assay manufacturer.

Limitations

Thresholds for distinguishing normal from partial GH deficiency have not been well established. Inadequate response to two different provocative tests is required for diagnosis of GH deficiency. Peak GH concentrations depend on the stimulation test performed and are described in Endocrine Society guidelines.

Test Details

New York Approved