Hereditary Gastric Cancer Panel, Sequencing and Deletion/Duplication

Casandra

Casandra Test Code AR71042Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 3005963CPT Codes 81201, 81203, 81292, 81294, 81295, 81297, 81298, 81300, 81317, 81319, 81403

Hereditary Gastric Cancer Panel, Sequencing and Deletion/Duplication

Also known as: GASCAN NGS

Clinical Use

Order Test

Use

This test is designed to confirm a hereditary cause of gastric cancer in individuals with a personal or family history of the disease. Pathogenic germline variants in multiple genes are linked to hereditary gastric cancer, which is often characterized by early disease onset (typically before 50 years of age) and multiple, multifocal, or similar cancers in a single individual or in closely related family members. Approximately 5-10 percent of gastric cancers are associated with hereditary causes.

Special Instructions

Testing minors for adult-onset conditions is not recommended; testing will not be performed in minors without prior approval. For more information, please contact the ARUP genetic counselor at 800-242-2787 ext. 2141. Additional submission requirements include a Hereditary Cancer Testing Patient History Form and Informed Consent for Genetic Testing, especially for New York clients.

Limitations

A negative result does not exclude a heritable form of gastric cancer or other cancers. This test only detects variants within the coding regions and intron-exon boundaries of the targeted genes. Deletions/duplications/insertions of any size may not be detected by massively parallel sequencing. Variants such as regulatory region variants and deep intronic variants will not be identified. The test is not intended to detect low-level mosaic or somatic variants, gene conversion events, complex inversions, translocations, mitochondrial DNA variants, noncoding transcripts, complex structural rearrangements, or repeat expansions.

Test Details