Hereditary Renal Cancer Panel, Sequencing and Deletion/Duplication

Casandra

Casandra Test Code AR69241Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 2010214CPT Codes 81292, 81294, 81295, 81297, 81298, 81300, 81317, 81319, 81321, 81323, 81351

Hereditary Renal Cancer Panel, Sequencing and Deletion/Duplication

Also known as: RENCAPAN

Clinical Use

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Use

The Hereditary Renal Cancer Panel is designed to confirm a hereditary cause of renal cancer in individuals with a personal or family history of the disease. Hereditary cancer predisposition often manifests with early-onset cancers (typically before age 50) and may involve multiple, multifocal, and related cancer types. This panel analyzes genes linked to variable phenotypes and cancer risks, including nonrenal cancers. Pathogenic germline variants identified in this testing can provide significant insights for patient management and familial risk assessment, assisting healthcare providers in developing personalized screening and treatment strategies.

Special Instructions

Testing should not be performed on minors for adult-onset conditions without prior approval. The Hereditary Cancer Testing Patient History Form must be submitted with the order. Specimens from New York clients will be sent to a New York state-approved laboratory. For inquiries, contact an ARUP genetic counselor.

Limitations

This test only detects variants within the coding regions and intron-exon boundaries of the targeted genes. It does not identify deletions/duplications/insertions outside these regions, nor does it detect regulatory or deep intronic variants. Technical limitations may prevent the detection of variants in pseudogenes, repetitive, or homologous regions, and the test is not intended to detect low-level mosaics, somatic variants, complex inversions, translocations, repeat expansions, or mitochondrial DNA (mtDNA) variants. Targeted regions that are not sequenced due to assay limitations include specific exons in FLCN, SDHA, SDHC, and VHL.

Test Details