HLA-DP Genotyping
Also known as: HLA-DP DNA
Use
HLA-DP genotyping is useful in immunization/vaccination trials and may aid in the clinical diagnosis of diseases associated with the HLA-DP locus. It provides medium to high resolution of the HLA-DP locus, aiding in the identification of alleles and potential disease associations.
Special Instructions
This test is performed by a non-ARUP laboratory, specifically the Histocompatibility & Immunogenetics Laboratory at the University of Utah Health. For single antigen HLA-DP identification, this test should be used. Interpretation of allele codes is accessible at the provided URL.
Limitations
The presence of a disease-associated HLA combination does not establish a diagnosis. Limitations exist if the number of reported alleles is fewer than two, suggesting homozygosity in the patient. Rare diagnostic errors due to primer or probe site mutations may occur. This test is not comprehensive for HLA evaluation for hematopoietic stem cell transplantation, and alternative panels by Next Generation Sequencing are suggested for pre-transplant allele matching.
New York Approved
Methodology
PCR-based (PCR)
Biomarkers
LOINC Codes
- 59018-2
- 59017-4
- 50398-7
Result Turnaround Time
3-7 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5 mL
Minimum Volume
3 mL
Container
Lavender (EDTA), Pink (K2EDTA), or Yellow (ACD Solution A or B)
Causes for Rejection
Green (Sodium or Lithium Heparin) tubes
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 1 week |
| Frozen | Unacceptable |