HLA-DQ Genotyping
Also known as: HLADQ DNA
Use
The HLA-DQ Genotyping test is useful in immunization/vaccination trials and aids in the clinical diagnosis of diseases strongly associated with the HLA-DQ locus. It can also help rule out celiac disease in cases where other testing is inconclusive, and is useful in identifying genetic predispositions linked to narcolepsy.
Special Instructions
Not provided.
Limitations
This test cannot establish a diagnosis solely based on the presence of a disease-associated HLA combination. Single allele reporting suggests homozygosity. Certain diagnostic errors may occur due to primer or probe site mutations, and it is not sufficient for comprehensive HLA evaluation necessary for hematopoietic stem cell transplantation assessment. Alternative comprehensive panels by NGS are recommended for pre-transplant matching.
New York Approved
Methodology
PCR-based (PCR)
Biomarkers
No genes
GeneNo genes
Gene
LOINC Codes
- 59019-0 - HLA-DQA1 High Res
- 57299-0 - HLA-DQB1 High Res
- 50398-7 - Narrative diagnostic report-Imp
Result Turnaround Time
3-7 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
5 mL
Minimum Volume
3 mL
Container
Lavender (EDTA), Pink (K2EDTA), or Yellow (ACD Solution A or B)
Storage Instructions
Refrigerated.
Causes for Rejection
Green (sodium or lithium heparin) tubes.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 72 hours |
| Refrigerated | 1 week |
| Frozen | Unacceptable |
Other tests from different labs that may be relevant