HLA-DR Genotyping

Casandra

Casandra Test Code AR47471Version 1 (DRAFT)

Performing Lab

Lab ARUP LaboratoriesLab Test ID 2002798CPT Code 81382

Also known as: HLA-DR DNA

Clinical Use

Order Test

Use

HLA-DR Genotyping is used for immunization/vaccination trials or to aid in the clinical diagnosis of diseases strongly associated with the HLA-DR locus. The test provides information critical for patients involved in treatment protocols requiring specific HLA-DR allele identifications. It assists healthcare providers in making informed clinical decisions for diagnosis or trial suitability based on HLA-DR genetic information.

Special Instructions

Order this test for single antigen HLA-DR identification. Please specify antigens. Refer to HLA-DQB Genotyping for single antigen HLA-DQB identification. The test is performed by a non-ARUP laboratory, specifically the Histocompatibility & Immunogenetics Laboratory at the University of Utah Health. Ensure proper specimen conditions as per the guidelines for accurate results.

Limitations

The presence of a disease-associated HLA combination does not establish a diagnosis. If less than 2 alleles are reported for a locus, the patient is likely homozygous. Rare diagnostic errors can occur due to primer or probe site mutations. This test is not sufficient for comprehensive HLA evaluation for clinical hematopoietic stem cell transplantation. For pre-transplant allele matching, consider HLA Class I and II Panel by Next Generation Sequencing. Occasionally, the specific allele cannot be determined, and the most likely allele assignment is made, indicating other possible allele assignments.

Test Details

New York Approved