Immunoglobulin G Subclass 4
Also known as: IGG4
Use
The Immunoglobulin G Subclass 4 test aids in the diagnosis or monitoring of IgG4-related diseases. Conditions such as primary immunodeficiency diseases, IgG4-related disease, primary sclerosing cholangitis, and eosinophil-related disorders can be associated with abnormal levels of IgG4. This test provides clinicians with valuable information for the evaluation of these conditions by measuring the specific subclass of IgG antibodies.
Special Instructions
It is important to separate serum from cells as soon as possible or within 2 hours of collection. The serum should be transferred to an ARUP Standard Transport Tube with a minimum volume of 0.5 mL for transport. Ensure that specimens are not grossly hemolyzed or lipemic, as these conditions are unacceptable.
Limitations
This test may not detect all conditions associated with IgG4-related disease. Conditions not related to IgG4 abnormalities will not be assessed through this test. Additionally, interfering substances such as hemolysis or lipemia in samples can result in inaccurate measurements, potentially affecting the clinical interpretation. The methodology used may have limited sensitivity and specificity beyond the measurement of IgG4 itself.
FDA ApprovedNew York Approved
Methodology
Immunoassay (Quantitative Immunoturbidimetry)
Biomarkers
LOINC Codes
- 2469-5
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Separate serum from cells ASAP or within 2 hours of collection. Transfer to an ARUP Standard Transport Tube.
Storage Instructions
Refrigerated
Causes for Rejection
Grossly hemolyzed or lipemic specimens
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | Unacceptable |
| Refrigerated | 14 days |
| Frozen | 6 months |