Inflammatory Bowel Disease Differentiation Panel
Also known as: IBD-PAN
Use
The Inflammatory Bowel Disease Differentiation Panel is recommended for the evaluation of patients at risk for inflammatory bowel disease. It is particularly useful in differentiating patients with ulcerative colitis (UC) from those with Crohn disease (CD). Detection of both Saccharomyces cerevisiae IgG and IgA antibodies in the same serum specimen is highly specific for Crohn disease. Atypical p-ANCA antibodies are commonly found in patients with ulcerative colitis.
Special Instructions
The test is performed on Monday, Wednesday, and Friday. ANCA IFA patterns are assessed on both ethanol- and formalin-fixed slides for better differentiation of C- and P-ANCA patterns. New York state approval is confirmed for this test.
Limitations
A negative result does not rule out inflammatory bowel disease (IBD). The antibody profile is indicative but does not replace the use of clinical, imaging, and/or biopsy studies in making a final diagnosis. While S. cerevisiae antibodies are prevalent in Crohn disease, their presence can also be observed in a smaller percentage of ulcerative colitis patients, thus making it important to use this panel in conjunction with other diagnostic criteria.
FDA ApprovedNew York Approved
Methodology
Immunoassay (Enzyme Immunoassay)
Biomarkers
LOINC Codes
- 47321-5
- 47320-7
- 62364-5
- 21419-7
- 29967-7
- 11526-1
Result Turnaround Time
1-4 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1.5 mL
Minimum Volume
0.6 mL
Container
ARUP standard transport tube
Collection Instructions
Separate serum from cells ASAP or within 2 hours of collection. Collect in a serum separator tube (SST).
Storage Instructions
Refrigerated.
Causes for Rejection
Contaminated, heat-inactivated, hemolyzed, or severely lipemic specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 48 hours |
| Refrigerated | 2 weeks |
| Frozen | 30 days (avoid repeated freeze/thaw cycles) |