Isopropanol (Includes Acetone)
Also known as: ISOP
Use
The test is used to monitor exposure to isopropanol. Isopropanol exposure can result in toxic concentrations that may cause symptoms such as nausea, dizziness, central nervous system depression, and potentially coma. Accurate measurement is critical to assess the exposure level and guide medical intervention. This toxicity profile is especially relevant in emergency toxicology for patients presenting symptoms consistent with chemical exposure.
Special Instructions
For accurate results, it is crucial to separate serum or plasma from cells as soon as possible, or within 2 hours of collection. Ensure that the ARUP Standard Transport Tube is tightly capped to minimize alcohol loss. A nonalcohol-based cleanser should be used at the venipuncture site when drawing blood specimens for alcohol testing to avoid contamination.
Limitations
There is no established therapeutic range for isopropanol, making exact interpretation reliant on known toxic thresholds. The methodology's detection limit is 5 mg/dL. Results exceeding 50 mg/dL for isopropanol and 100 mg/dL for acetone are considered toxic and may cause significant symptoms. Whole blood specimens, Plasma Separator Tubes (PST), and Serum Separator Tubes (SST) are unacceptable for this test due to potential interference or contamination.
New York Approved
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 5568-1
- 5669-7
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
3 mL
Minimum Volume
0.5 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Use a nonalcohol-based cleanser at the venipuncture site. Separate serum or plasma from cells as soon as possible or within 2 hours. Ensure the tube is capped tightly to minimize alcohol loss.
Patient Preparation
Timing of specimen collection is dependent on the time of exposure; test upon presentation to hospital.
Storage Instructions
Refrigerated
Causes for Rejection
Whole blood. Plasma Separator Tubes (PST), Serum Separator Tubes (SST).
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 1 week |
| Refrigerated | 2 weeks |
| Frozen | 1 month |