Lamotrigine
Also known as: LAMOT
Use
Lamotrigine testing is critical for therapeutic drug monitoring to optimize drug therapy and patient adherence. It is essential for patients on lamotrigine treatment, as pharmacokinetics can vary widely due to co-medications and renal function status, impacting therapeutic efficacy and risk of adverse effects.
Special Instructions
For accurate monitoring, the timing of specimen collection is important. The specimen should be collected pre-dose (trough) when the patient has reached steady-state concentration.
Limitations
Pharmacokinetics of lamotrigine vary widely among individuals, especially in the presence of co-medications or compromised renal function. It is important to note that adverse effects such as dizziness, somnolence, nausea, and vomiting may occur, which could affect the interpretation of dosage efficacy and toxicity levels.
New York Approved
Methodology
Immunoassay (Quantitative Enzyme Immunoassay)
Biomarkers
LOINC Codes
- 6948-4
Result Turnaround Time
1 day
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.3 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Separate serum or plasma from cells ASAP or within 2 hours of collection.
Patient Preparation
Pre-dose (trough) draw at steady state concentration.
Storage Instructions
Refrigerated.
Causes for Rejection
Serum or plasma separator tubes, grossly hemolyzed specimens.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 7 days |
| Refrigerated | 1 week |
| Frozen | 4 weeks |