Leukotriene E4, Random Urine
Also known as: LTE URN
Use
The Leukotriene E4 (LTE4) test on random urine is used for the initial evaluation of suspected cases of mast cell activation disorders. It is an important test for diagnosing conditions related to systemic mast cell activation, which can lead to the release of leukotrienes such as LTE4, causing various allergic and inflammatory reactions. A 24-hour urine collection is preferred for more accurate results, particularly when evaluating chronic conditions or symptomatic presentations associated with mast cells.
Special Instructions
Patients taking 5-lipoxygenase inhibitors such as Zileuton or Zyflo may have decreased concentrations of leukotriene E4. It is recommended to discontinue such medications 48 hours prior to sample collection to avoid interference with test results. This test is not performed at ARUP Laboratories directly; therefore, separate specimens must be submitted if multiple tests are ordered simultaneously.
Limitations
The test has performance characteristics developed consistent with CLIA requirements but has not been cleared or approved by the U.S. Food and Drug Administration. As it requires non-standard processing (performed at an external laboratory), results could be influenced by laboratory-to-laboratory variability. Interference by medications such as 5-lipoxygenase inhibitors can alter leukotriene levels, affecting test results.
New York Approved
Methodology
Mass Spectrometry
Biomarkers
LOINC Codes
- 2161-8
- 33343-5
- 33343-5
- 2161-8
Result Turnaround Time
7-12 days
Related Documents
For more information, please review the documents below
Specimen
Urine
Volume
5 mL
Minimum Volume
2 mL
Container
ARUP standard transport tubes
Collection Instructions
Collect urine and transfer 5 mL to ARUP standard transport tubes (minimum 2 mL).
Patient Preparation
Discontinue 5-lipoxygenase inhibitors 48 hours prior to collection.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 24 hours |
| Refrigerated | 1 week |
| Frozen | 28 days |