Lymphocyte Subset Panel 7 - Congenital Immunodeficiencies
Also known as: PIP
Use
The Lymphocyte Subset Panel 7 is a quantitative flow cytometry test used in the investigation of primary immunodeficiency disorders. This test evaluates and enumerates the percentages and absolute cell counts of lymphocyte subsets in lysed whole blood. It aids in identifying inherited immunodeficiencies, such as X-linked hypogammaglobulinemia, DiGeorge syndrome, bare lymphocyte syndrome, and severe combined immunodeficiency disease (SCID). The test helps in assessing defects in antibody formation, evaluating helper and cytotoxic T-cells, B-cells, and natural killer (NK) cells, and provides insight into the immune status of patients with suspected or known immunodeficiencies.
Special Instructions
Not provided.
Limitations
This test does not detect all possible defects in immune function. Immunophenotyping is generally not useful in characterizing selective IgA deficiency, IgG subclass deficiencies, hyper IgM syndrome, or hyperimmunoglobulin E syndrome (Job syndrome). The test has not been cleared or approved by the US Food and Drug Administration but is performed in a CLIA certified laboratory and is intended for clinical purposes. Results must be interpreted within the context of the patient's clinical history and other laboratory findings. Delays in specimen processing and improper sample handling may affect test results.
New York Approved
Methodology
Cell-based / Cytometry (Flow Cytometry)
Biomarkers
LOINC Codes
- 48767-8 - Annotation comment Imp
- 33617-2 - HLA-DR+ Cells # Bld
- 15195-1 - Cells.CD3-CD19+ # Bld
- 32519-1 - CD3-CD16+CD56+ Cells NFr Spec
- 20604-5 - CD3-CD16+CD56+ Cells # Spec
- 34475-4 - CD4+CD45RO+ Cells # Bld
- 41994-5 - CD4+CD45RO+ Cells NFr Bld
- 26759-1 - CD4+CD45RA+ Cells # Bld
- 17157-9 - CD45RA Cells NFr Bld
- 31113-4 - HLA-DR+ Cells NFr Bld
- 8122-4 - CD3 Cells # Bld
- 20599-7 - CD3 Cells NFr Spec
- 24467-3 - CD3+CD4+ Cells # Bld
- 14135-8 - CD3+CD8+ Cells # Bld
- 8123-2 - CD3+CD4+ Cells NFr Bld
- 32518-3 - CD3+CD8+ Cells NFr Spec
- 20593-0 - CD19 Cells NFr Spec
- 54218-3 - CD3+CD4+ Cells/CD3+CD8+ Cll Bld
- 8118-2 - CD2 Cells NFr Bld
- 9557-0 - CD2 Cells # Bld
Result Turnaround Time
1-3 days
Related Documents
For more information, please review the documents below
Specimen
Whole Blood
Volume
4 mL
Minimum Volume
0.5 mL
Container
Lavender (EDTA), pink (K2EDTA), or green (sodium or lithium heparin) tubes
Collection Instructions
None specified.
Patient Preparation
None specified.
Storage Instructions
Critical room temperature.
Causes for Rejection
Clotted or hemolyzed specimens
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | EDTA: 72 hours; Heparin: 48 hours |
| Refrigerated | Unacceptable |
| Frozen | Unacceptable |
Other tests from different labs that may be relevant