Macroprolactin
Also known as: MACROPRO
Use
The Macroprolactin test is used to identify the proportions of macroprolactin and monomeric prolactin. A high percentage of macroprolactin in the presence of high total prolactin levels is important for differential diagnosis of hyperprolactinemia. This condition can lead to symptoms such as infertility, galactorrhea, and menstrual disorders in women, and low testosterone levels in men.
Special Instructions
Patient specimens should be collected either in a serum separator tube or a plasma separator tube. Lithium heparin or EDTA plasma is also acceptable. Allow specimen to clot completely at room temperature before processing.
Limitations
The test's interpretative data indicates that if the percentage of Monomeric Prolactin is between 40-50%, the result is indeterminate for macroprolactin. Less than 40% monomeric prolactin suggests the presence of macroprolactin. Additionally, monomeric prolactin above the upper reference limit suggests hyperprolactinemia. Testing prolactin in suspected prolactinoma during pregnancy is not recommended due to varying reference ranges.
New York Approved
Methodology
Immunoassay (CLIA)
Biomarkers
LOINC Codes
- 42607-2
- 50366-4
- 20568-2
Result Turnaround Time
1-8 days
Related Documents
For more information, please review the documents below
Specimen
Serum
Volume
1 mL
Minimum Volume
0.5 mL
Container
ARUP Standard Transport Tube
Collection Instructions
Allow specimen to clot completely at room temperature before transferring to the transport tube.
Stability Requirements
| Temperature | Period |
|---|---|
| Room Temperature | 8 hours |
| Refrigerated | 7 days |
| Frozen | 1 month |